Another type of leukodystrophy, adult-onset autosomal dominant leukodystrophy (ADLD) is characterized by duplication of the gene that codes for lamin B1 (LMNB1), which leads to overexpression of LMNB1 and causes severe myelin loss [160]. The gene discussed is LMNB1; the disease is adult-onset autosomal dominant demyelinating leukodystrophy.