Interestingly, even in pHGG, PATZ1 expression is associated positively with proneural genes and negatively with mesenchymal genes of the adult neoplasms, thus suggesting a common mechanism of action of PATZ1 in both adult and childhood glial tumors, likely based on the counteraction of the proneural-to-mesenchymal transition (PMT) [19]. This evidence concerns the gene PATZ1 and neoplasm.