As each of the isoforms have been related to different diseases, i.e., NOX1, to diabetic atherosclerosis and retinopathy, NOX2, to neurodegeneration, NOX4, to stroke, diabetic nephropathy, and neuropathic pain, and NOX5, to diabetic nephropathy, hypertension, and coronary artery disease, isoform-specific targeting could represent a treatment solution. The gene discussed is NOX5; the disease is diabetic kidney disease.