TGFB1 and hepatocellular carcinoma: Interestingly, TGF-β induces intracellular release of Ca2+ ion in human hepatoma cells, by increasing the expression levels of Na+/Ca2+ exchanger 1 (NCX1) and the canonical transient receptor potential channel 6 (TRPC6), in addition to enhancing the NCX1-TRPC6 interaction.