Similarly, TGF-β induces myocyte enhancer factors 2 (MEF2) expression in HCC cells in a PI3K/Akt-dependent manner, and MEF2 in turn acts as a transcription factor to activate TGF-β transcription, creating another positive feedback loop and promoting HCC cell motility [77]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.