In contrast, IQGAP1 associates with TβRII upon TGF-β stimulation in hepatic stellate cells (HSCs), and promotes Smurf1-mediated TβRII ubiquitination and degradation, thereby inhibiting differentiation of HSCs into myofibroblasts and preventing metastatic growth of lung cancer cells and colon cancer cells [110]. This evidence concerns the gene TGFBR2 and lung cancer.