Although gene expression variation of TGF-β signaling components has been connected with liver cancer progression, as most notably exemplified by TGF-β upregulation and TβRII downregulation [9,68], it is now apparent that signaling robustness and duration play a pivotal role in determining the versatile and context-specific functions of TGF-β [30,36,37,43]. Here, TGFB1 is linked to liver cancer.