Recently, Ferrari et al. (2019) demonstrated that Dickkopf-3 (DKK3), the stromal expression of which is strongly associated with aggressive ovarian cancer, promotes CAFs’ aggressive behavior by enhancing Yes-associtated protein/transcriptional co-activator with PDZ-binding motif (YAP/TAZ) activity through Wnt/β-catenin signaling [126]. This evidence concerns the gene DKK3 and ovarian cancer.