Hyperglycemia and hypoinsulinemia were present in the 60-week-old OLETF rats, and the plasma glucose, TG, Cho, and insulin concentrations were 271 ± 5 mg/dL, 358 ± 13 mg/dL, 269 ± 14 mg/dL, and 59 ± 3 ng/dL, respectively (mean ± S.E.; n = 3). This evidence concerns the gene INS and Hyperglycemia.