We further investigated the expression of COX-1, COX-2, PTGES3, and TERT genes, using bioinformatics analysis on the TCGA-COAD and READ datasets, and found that COX-1 and COX-2 are mainly correlated to TERT expression, and that high COX-2 expression is associated with a better overall survival of the CRC patients. The gene discussed is PTGS2; the disease is colorectal carcinoma.