Additionally, Sj16, a secreted protein of Schistosoma japonicum, has immunoregulatory protective effects on dextran sulfate sodium (DSS)-induced colitis by inhibiting the peroxisome-proliferator activated receptor-alpha (PPAR-α) signaling pathway, increasing Treg percentages and up-regulating anti-inflammatory factors production [81]. This evidence concerns the gene PPARA and colitis.