CTNNB1 and infectious otitis media: Given the different mutation site in genes such as Ctnnb1 (the Ctnnb1 gene encodes β-catenin), it is evident that the combination of AOM and an inflammatory agent induces a different spectrum of tumors in comparison to induction by the carcinogen alone (reviewed in Reference [54]; all indicated models of chemically induced colorectal tumorigenesis are summarized in Table S1, Supplementary Materials).