To assess the Egfr function in immune-mediated colitis, Egfrwa5/wa5 mice were treated with AOM/DSS and crossed with interleukin 10 (Il10)-deficient (Il10−/−) mice, a strain that represents a model of spontaneous colitis with many characteristics of human inflammatory bowel disease (IBD). The gene discussed is EGFR; the disease is inflammatory bowel disease.