Mutations of critical components involved in PI3K-mediated signaling, i.e., in PIK3, phosphatase and tensin homolog (PTEN; the gene encodes a dual-specificity phosphatase that antagonizes PI3K signaling [189]), and AKT occurred in 13–32%, 14%, and 1–6% of human CRC samples, respectively [190,191]. This evidence concerns the gene PTEN and colorectal carcinoma.