Interestingly, the presence of KrasLA1 and KrasLA2 alleles on the Apc+/Min and Trp53−/− genetic background had—presumably due to the low incidence of oncogenic Kras allele activation—no or little effect on ACF progression, The only detectable effect was occurrence of several adenocarcinomas in the duodenum [164]. This evidence concerns the gene APC and adenocarcinoma.