However, after crossing with Apc+/Min mice and Cre induction with β-naphthoflavone, the compound mutants (KrasAsp12 Ah-Cre Apc+/Min) displayed a much severer phenotype than Apc+/Min mice, i.e., decreased lifespan and elevated amounts of small intestinal and colonic tumors [177]. This evidence concerns the gene APC and colonic neoplasm.