CD4 and lobular neoplasia: More recently it was also shown in the (NZB × NZW) F1 model that treatment with IL-2/anti-IL-2 complexes induced an expansion of the Treg population in the kidneys, which was accompanied by a reduction of kidney-infiltrating IFN-γ+CD4+ and IL-17A+CD4+ T cells and an amelioration of LN at a histomorphological and clinical level [35].