Briefly, we have shown that in addition to Galcer, both Cer and Sph are necessary components for myelinogenesis, maintaining a defined ratio of Cer/dhCer and Sph/dhSph during the rat brain development and a higher ratio is observed in MS due to accumulation of Cer and Sph that lead to oligodendrocyte death and thereby fostering demyelination. Here, CBLN1 is linked to myeloid sarcoma.