It is worth noting that fasting-induced hepatic steatosis was shown to be impaired in liver-specific Atg5-deficient mouse liver in another study, in which further deletion of nuclear factor erythroid 2-related factor 2 (NRF2) was able to rescue impaired lipid droplet formation in Atg5-deleted livers [48]. Here, ATG5 is linked to Hepatic steatosis.