Another interesting study designed engineered adipose-derived mesenchymal stem cells to overexpress miR-181-5p, and found that exosomes from these cells were able to transfer miR-181-5p to mouse hepatic stellate (HST-T6) cells or a carbon tetrachloride (CCL4)-induced liver fibrosis mouse model, leading to inhibition of fibrosis pathway and CCL4-induced liver fibrosis by autophagy activation [55]. The gene discussed is CCL4; the disease is Hepatic fibrosis.