GnRH receptor (GnRH-R) presence has already been proved by displacement binding assays on KB oral and HEp-2 laryngeal carcinoma cells [24], while high GnRH-R expression and cell surface localization, moreover effective cellular uptake of GnRH analogs, has been demonstrated on Detroit-562 human pharynx tumor cells [40]. The gene discussed is GNRH1; the disease is laryngeal carcinoma.