MET and neoplasm: Jørgensen et al postulate that a heterogenous signal pattern is associated with MET amplification in gastroesophageal tumour specimens, showing 12 out of 159 tumour samples tested exhibited heterogeneous signal distribution, eight (66%) out of the 12 specimens were MET amplified; MET amplification in this instance was defined as MET centromere 7 gene ratio ≥2.0 by these authors [23].