However, while all patients exhibited a significant decrease in general CD3 T-cell proliferation (p = 0.025) (Fig 5B), deeper analysis into T-cell subset revealed the decreased proliferation in CD4 T-cell compartment in PAD (p = 0.025) (Fig 5C) while the decreased proliferation was found in the CD8 T-cell compartment in SAD patients (p = 0.042) (Fig 5D). Here, CD4 is linked to peripheral arterial disease.