In the context of lung inflammation, ErbB2 is upregulated in whole lung lysates in murine bleomycin models of lung injury and EGFR ligands are increased in BAL from acute lung injury patients receiving mechanical ventilation (Finigan et al., 2011), suggesting ErbB signalling axes may play a role in the process of airway inflammation in vivo. Here, ERBB2 is linked to acute lung injury.