Once covalently conjugated by click chemistry, we confirmed that recognition properties are conserved without pre‐immunization, and more importantly, that the ARM is able to promote the formation of a ternary complex between natural IgM and cancer cells, which is required for the stimulation of cytotoxic immune response in vivo.5, 6 These experiments are currently performed in our group and will be reported in due course. Here, CD40LG is linked to cancer.