In another study, a bifunctional molecule containing nitrophenol to bind endogenous IgM and the modified NeuAcα2‐6Galβ1‐4GlcNAc trisaccharide to target CD22‐expressing B‐cell lymphomas has been described.12 It was demonstrated that this ligand uses IgM as a protein scaffold to bind on the surface of B‐cells in a multivalent fashion to promote immune response. This evidence concerns the gene CD40LG and B-cell non-Hodgkin lymphoma.