While Aβ aggregation is thought to occur at the early stages of AD, tau aggregation correlates better to disease progression, with characteristic spreading along linked brain areas, and severity of symptoms correlating to the number of observed inclusions (Tanzi, 2012; Hardy and Selkoe, 2002; Manczak and Reddy, 2014; Seward et al., 2013; Brier et al., 2016; Schwarz et al., 2016). Here, MAPT is linked to Alzheimer disease.