Herein, we found eight hub genes for the progression of COAD, including BGN, SULF1, COL1A1, FAP, THBS2, CTHRC1, COL5A2, and COL1A2. These genes may contribute to the exploration of the progression of COAD and could be regarded as biomarkers and therapeutic targets of COAD. This evidence concerns the gene COL5A2 and colon adenocarcinoma.