Removing individuals with high skull/meningeal retention did not result in increased area under the curve in receiver operator characteristic curves when comparing AD patients with controls in tau imaging stages I/II or I–IV, suggesting that this off-target binding in the skull does not significantly affect the diagnostic accuracy in these regions (stage I/II: AUC all subjects, 0.986, 95% CI [0.977–0.996]; AUC w/o high, 0.986, 95% CI [0.977–0.996]). This evidence concerns the gene MAPT and Alzheimer disease.