Although other researches have demonstrated that growth restriction of diabetes pregnant patients' offspring suffered a higher risk of subsequent obesity and type 2 diabetes [42, 43], both female and male F1 offspring in this study remained having a lighter body weight until week 20, with a smaller area under the OGTT curve and higher insulin levels at 12 and 16 weeks (). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.