On the other hand, L. fermentum KBL375 treatment showed the up-regulation of anti-inflammatory cytokine IL-10 and TGF-β in AD-induced mice indicating that the suppression of immune responses were occurred (Figure 4) (Agrawal et al., 2011; Kosaka et al., 2011; Purchiaroni et al., 2013). This evidence concerns the gene TGFB1 and Alzheimer disease.