However, after 28 days of L. fermentum KBL375 administration, clinical features including dermatitis score, TEWL, scratching behavior, and serum IgE levels, which are considered typical abnormalities induced by AD, improved significantly (Figure 1) (Brandt, 2011; Lee and Yu, 2011; Zheng et al., 2011; Galli and Tsai, 2013). Here, IGHE is linked to Alzheimer disease.