At the clinical level, APS is defined by the occurrence of thrombotic events, with the peculiar trait of potentially involving both arteries and veins and/or pregnancy morbidity, in individuals found to be persistently positive for antiphospholipid antibodies (aPL), including: lupus anticoagulant (LA), anti-cardiolipin (aCL), and anti-β2glycoprotein I (anti-β2GPI) antibodies (1). Here, FASLG is linked to autoimmune polyendocrinopathy.