SEMA4D and non-small cell lung carcinoma: It has been shown that VEGF-A regulates the expression of the axon guidance factor semaphorin 4D (Sema4D) (95), which has been identified as a promotor of VM in non-small cell lung cancer (96), where the recognition of Sema4D by the plexin B1 receptor activates the small GTPase RhoA, which is implicated cell motility.