Indeed, Ras guanosine triphosphate (Ras-GTP) has been documented in cell lines and primary brain tumors, and it is able to translate extrinsic signals into the Raf-MEK-Erk, or into either the PI3K-PKB or the PI3K-Rac-Rho pathways, which influence cell survival and migration (11–13). This evidence concerns the gene AKT1 and brain neoplasm.