These results suggest for the first time a possible transduction mechanism of compression through MEK1/Erk1/c-Jun signaling axis in brain cancer cells, being more evident in the less aggressive H4 cells and to a less extent in A172 GBM cells, as indicated through a validation of the phospho-protein hits by Western Blotting (Figures 7C,D). This evidence concerns the gene JUN and glioblastoma.