In particular, RhoB has been found to be expressed in high-grade glioma, while depletion of this molecule impaired proliferation and survival of GBM cells through a STAT3-dependent regulation of p53 and p21 expression, and that knockdown of RhoB found to impair the in vivo tumorigenic potential of GBM cells (16). The gene discussed is STAT3; the disease is glioblastoma.