In particular, RhoB has been found to be expressed in high-grade glioma, while depletion of this molecule impaired proliferation and survival of GBM cells through a STAT3-dependent regulation of p53 and p21 expression, and that knockdown of RhoB found to impair the in vivo tumorigenic potential of GBM cells (16). This evidence concerns the gene RHOB and glioblastoma.