Moreover, an higher methylation of transcription factor AP-2 alpha (TFAP2A) and early B-cell factor 2 (EBP2) was found in patients with blastic phase with respect chronic phase, and autophagy related 16-like 1 (ATG16L1) was methylated in 69% of CML patients. Here, TFAP2A is linked to chronic myelogenous leukemia, BCR-ABL1 positive.