ATG16L1 and chronic myelogenous leukemia, BCR-ABL1 positive: Moreover, an higher methylation of transcription factor AP-2 alpha (TFAP2A) and early B-cell factor 2 (EBP2) was found in patients with blastic phase with respect chronic phase, and autophagy related 16-like 1 (ATG16L1) was methylated in 69% of CML patients.