Interestingly, some of the over-expressed genes in CML-LSCs encode cell surface proteins, such as IL2Rα (CD25), DPP4 (CD26), PTPRD, CACNA1D, IL1RAP, SLC4A4, and KCNK5. This evidence concerns the gene IL1RAP and chronic myelogenous leukemia, BCR-ABL1 positive.