Importantly, obtained results demonstrate that these inhibitors could induce apoptosis of Kv1.3-expressing cancer cell lines even in absence of Bax or Bak pro-apoptotic proteins, such as in case of Bax/Bak-deficient human leukemic Jurkat T cells and murine embryonic fibroblasts (MEF DKO cells) (41). Here, KCNA3 is linked to cancer.