In this study, we used DHEA to induce a PCOS mouse model and found that the percentages of M1 macrophages and neutrophils were increased in both the peripheral blood and spleen of DHEA-induced mice and the percentages of splenic IFN-γ+T helper cells (Th1), IL-17A+T helper cells (Th17), and IFN-γ+CD19+B cell were also increased, and the expression of proinflammatory factors (TNF-α, IL-1β, and IFN-γ) in the ovarian and uterine tissues was increased. Here, IFNG is linked to polycystic ovary syndrome.