The lower degree of DNA hypomethylation reached via the glyphosate-TET3 path compared to that reached via UP peptide-DNMT1 path that is capable of inducing tumor onset suggests that a great intensity of global DNA hypomethylation could act as an oncogenic event, while a moderate intensity of global DNA hypomethylation might be considered a predisposing factor to cancer. The gene discussed is DNMT1; the disease is cancer.