Besides, mir-17-92 cluster has been revealed to promotes the proliferation and the chemokine production of keratinocytes (146), mir-let-7b has been shown to inhibit keratinocyte differentiation by targeting IL-6 mediated ERK signaling in psoriasis (147), mir-194 has been demonstrated to regulate keratinocyte proliferation and differentiation via Grainyhead-like 2 in psoriasis (148). This evidence concerns the gene GRHL2 and psoriasis.