Moreover, anti-inflammatory TAMs induce S100A8 and S100A9 expression on HCC cancer cells (76), release CCL22 and epidermal growth factor (EGF) to recruit Treg cells, and promote migration of tumor cells, altogether contributing to HCC malignancy and liver metastasis (Figure 2) (77). This evidence concerns the gene S100A8 and hepatocellular carcinoma.