The expressions of Sdcs in gingival tissue correlated differentially with the presence of inflammatory infiltrate in control and periodontitis group – in control group, no correlation was found for Sdc1, whereas Sdc2 correlated positively and Sdc4 correlated negatively; in periodontitis group both Sdc1 and Sdc2 correlated positively with the presence of inflammatory infiltrate, and no correlation was found for Sdc4. This evidence concerns the gene SDC4 and periodontitis.