The expressions of HS biosynthesis (EXT1, EXT2, NDST1, and NDST2) and degradation enzymes (HPSE1) display similar correlation patterns with the presence of inflammatory infiltrate in gingival tissue from control and periodontitis group – EXT1, EXT2, and NDST1 correlate positively, whereas negative correlation was found for NDST2 and HPSE1. The gene discussed is NDST1; the disease is periodontitis.