This increased knowledge on the activities triggered by GC-C activation has guided the development of novel therapeutic approaches to gastrointestinal disorders (Waldman and Camilleri, 2018), including constipation, which resulted in the clinical use of linaclotide, a synthetic 14-peptide, potent and selective agonist of GC-C and, more recently, of plecanatide and dolcanatide (Hannig et al., 2014; Shailubhai et al., 2015; Al-Salama and Syed, 2017; Laus et al., 2018). Here, GUCY2C is linked to digestive system disorder.