This has been demonstrated in studies showing inhibition of antigen-induced asthma by U0126 (ERK inhibitor) (Duan et al., 2004), SB239063 (p38 inhibitor) (Underwood et al., 2000), or PD98059 (JNK inhibitor) (Eynott et al., 2004) in mouse models of allergic airway inflammation. Here, MAPK8 is linked to asthma.