HMOX1 and allergic asthma: In addition, we investigated the modulation of mitogen-activated protein kinase (MAPK)/NF-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) and nuclear factor-κB (NF-κB) activations to identify the mechanism underlying the anti-oxidant and anti-inflammatory effects of AE allergic asthma.