EPHX2 and eosinophilic esophagitis: However, since allergen-induced AHR remained elevated, dual inhibition of the COX-2 and sEH pathways may be useful in the treatment of conditions where eosinophilic inflammation with no bronchial reactivity, e.g., eosinophilic esophagitis, dermatologic disorders, and pain-associated inflammation co-exist, with the additional advantage of reducing side effects associated with COX inhibitors.