In summary, dual inhibition of the COX-2 and sEH pathways was as effective as inhibition of sEH alone with respect to reducing eosinophilia, restoring various lipid mediator levels and decreasing airway structural changes but not with inhibiting levels of Th2-promoting inflammatory mediators in a significant manner (IL-4, IL-13, and eotaxin-2) in an A. alternata-induced model of AAI. This evidence concerns the gene EPHX2 and Increased total eosinophil count.