ANGPT2 and ischemic stroke: Transgenic overproduction of omega-3 polyunsaturated fatty acids in mice recovers post-stroke revascularization and increases endogenous angiogenesis by inducing angiopoietin 2 production in astrocytes, which consequently stimulated endothelial cell proliferation and BBB formation, proposing that the integration of omega-3 polyunsaturated fatty acids is a possible angiogenic treatment able to increase brain repair and improve long-term functional recovery after ischemic stroke (Wang et al., 2014).