Furthermore, GC and GR dysregulations are involved in lots of functions disturbed in AD: i.e., dysregulation of the amyloid precursor protein (APP) processing, Tau phosphorylation, neuroinflammation, oxidative stress and excitotoxicity (Sapolsky, 1996; McEwen, 2008; Bengoetxea et al., 2016). This evidence concerns the gene APP and Alzheimer disease.