As previously reported, GRP75 overexpression in human DAergic cells enhanced vulnerability to ROT-induced cytotoxicity (Jin et al., 2006), but in vivo GRP75 overexpression reduced infarct size and protected against mitochondrial damage in a rat middle cerebral artery occlusion model of stroke (Xu et al., 2009) and a rat model of intracerebral hemorrhage (ICH) (Lv et al., 2017). This evidence concerns the gene HSPA9 and intracerebral hemorrhage.