In addition to its effect on histone proteins, VPA can also influence the protein levels of non-histone proteins such as p53 (Cook et al., 2004[8]), Ku70 (Jordan et al., 2000[22]), Bcl-2, Bax, and caspase-3 that are important in cancer growth, apoptosis, DNA repair, differentiation, and cell cycle control (Huang et al., 1999[19]; Takabuchi et al., 2004[38]; Thomas et al., 2004[41]). Here, BCL2 is linked to cancer.