FGF-10 also has been recorded to induce cell migration and invasion of pancreatic cancer cells CFPAC-1 and AsPC-1 via interaction with FGFR2-IIIb (a particular FGFR2 isoform) and by induction of MT1-MMP (membrane type 1-matrix metalloproteinase) and TGF-1b (transforming growth factor-b1) mRNA expression. The gene discussed is FGFR2; the disease is familial pancreatic carcinoma.