Although model systems strongly implicate TF dysregulation in this disease, in patient material only a few common transcription factor abnormalities are known (e.g., PML-RARA, RUNX1-ETO, Inv16, CEPBA) and these are mainly associated with particular cytogenetic subsets of AML [36]. The gene discussed is RUNX1T1; the disease is acute myeloid leukemia.