In multivariate analysis, intrahepatic metastasis (HR 8.29 [95% CI 2.28–30.17], p = 0.001 by the Cox proportional hazard model), Albumin-Bilirubin (ALBI) grade (HR 2.13 [95% CI 1.10–4.13], p = 0.026 by the Cox proportional hazard model), and liver cirrhosis (HR 2.01 [95% CI 1.08–3.72], p = 0.028 by the Cox proportional hazard model) were independent predictive factors for early IHR. This evidence concerns the gene ALB and cirrhosis of liver.