Of note, and in line with our observation in oma1−/− MEFs, the steady-state levels of the key components of mitochondrial fusion (mitofusins MFN1 and MFN2, and long and short isoforms of OPA1) and fission (DRP1) machinery remained largely unaltered in OM.21 (data not shown). This evidence concerns the gene OPA1 and ocular melanoma.