Akin to oma1−/− MEFs [28], the bioenergetics profiling of OM.21 cells revealed these cells were unable to maximize their respiration in response to mild uncoupling (Supplementary Fig. S4) and had significantly lower respiratory control ratios when cultured in the respiration-enforcing medium containing 10 mM galactose. The gene discussed is OMA1; the disease is ocular melanoma.