In order to select the most promising ligand for clinical translation, [64Cu]DOTA-R01, [64Cu]DOTA-R01-MR, and [64Cu]DOTA-R01-MG were first evaluated in mouse models with αvβ6 expressing BxPC3 pancreatic cancer xenografts (Fig. 1d, Supplementary Fig. 4, and Table 3). This evidence concerns the gene NR3C2 and familial pancreatic carcinoma.