E2F4 and colorectal carcinoma: When evaluating the top seven most strongly represented CRC-associated TFs by significance (redundant siRNA activity (RSA) Down/Up) and magnitude (Q1/3), we observed an early “drop-out” of HSCP-HK TFs (MYC, E2F4, MAZ, TEAD1, and NFE2L2), indicative of a role in maintaining stem cell function (Fig. 4b).