Immunofluorescence results also revealed that the tumors in the Mφ + CCX + BTZ group had lower CD138 levels and higher active caspase-3 levels than in the Mφ + BTZ group; thus, with CCX140-B treatment, more MM cells underwent apoptosis upon bortezomib treatment (Fig. 3d). Here, CASP3 is linked to Miyoshi myopathy.