Regardless, it is important to note that a significant subset of Mo/MΦs that are typically not appreciated within the tumor microenvironment due to the lack of expression of CD14 and/or SIRPα, are in fact functionally relevant in that they regulate T-cell function and can phagocytose malignant cells particularly in the presence of monoclonal antibodies. This evidence concerns the gene CD14 and neoplasm.