Both IHC and Western blot (WB) analysis confirmed marked accumulation of p53 in WM+T tumor cells, clearly evident by 3 d post-MycERT2 activation (Fig. 1I and SI Appendix, Fig. S1O) and accompanied by robust induction of the p53 target genes Puma, Noxa, and Cdkn1a (Fig. 1J). The gene discussed is BBC3; the disease is neoplasm.