Both IHC and Western blot (WB) analysis confirmed marked accumulation of p53 in WM+T tumor cells, clearly evident by 3 d post-MycERT2 activation (Fig. 1I and SI Appendix, Fig. S1O) and accompanied by robust induction of the p53 target genes Puma, Noxa, and Cdkn1a (Fig. 1J). Here, PMAIP1 is linked to neoplasm.