Sox2 similarly associates with the 1000+ bp site in select cancer cell populations such as thyroid gland medullary carcinoma and esophageal SCC [64] The third site at ~ 68,000 bp downstream of the TSS is bound by Sox2 in ESCs and iPSCs [62, 63, 82–84]. This evidence concerns the gene SOX2 and medullary thyroid gland carcinoma.