FASN and cancer: The top SSV-CGI associations involving the rearrangement of a region of low methylation (average methylation beta difference < − 0.1), with corresponding decrease in methylation and increase in expression being observed in the cancer case (< − 4SD and > 0.4SD from median, respectively), involved 314 unique cancer cases and 549 unique genes (Additional file 10), including genes such as TERT (14 cases) and FASN (5 cases, Fig. 5d).