For example, SSVs associated with the upregulation of CD274 and PDCD1LG2 involved ~ 1% of non-amplified cases in the PCAWG cohort of 1220, but these significant patterns involved lymphomas and other cancer cases that were not represented in the other previous study of 1448 cases, and so these genes were not significant in that study. Here, PDCD1LG2 is linked to lymphoma.