EZH2 and cancer: A number of possible mechanisms would be at work in DNA methylation alterations in cancer, including disruption of genes involved with methylation such as DNA methyltransferases (DNMTs), modifications of histones (e.g., by deregulation of enhancer of zeste drosophila homologue 2, or EZH2) that mark a gene for hypermethylation, and processes involved in DNA repair of double-stranded breaks [11, 36].